Abstract
Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described.
MeSH terms
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Analgesics, Opioid / adverse effects
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Analgesics, Opioid / chemistry*
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Analgesics, Opioid / pharmacology
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Cisapride / analogs & derivatives
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Cisapride / chemistry
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Cisapride / pharmacology
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Gastrointestinal Transit / drug effects
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Humans
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Metoclopramide / chemistry
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Metoclopramide / pharmacology
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Receptors, Opioid, mu / agonists*
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Receptors, Opioid, mu / metabolism
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Receptors, Serotonin, 5-HT4 / metabolism
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Respiratory System / drug effects
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Serotonin 5-HT4 Receptor Agonists*
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Stereoisomerism
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Tramadol / chemistry
Substances
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Analgesics, Opioid
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Receptors, Opioid, mu
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Serotonin 5-HT4 Receptor Agonists
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norcisapride
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Receptors, Serotonin, 5-HT4
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Tramadol
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Metoclopramide
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Cisapride